Israel says it has hit dozens of targets in Syria belonging to the government and allied Iranian forces.
The Israeli military says the “wide-scale strikes” responded to rockets fired by an Iranian unit into Israel.
Syria says two civilians died and that Syrian air defences shot down most of the missiles over Damascus. Other reports say the death toll was higher.
Local reports said loud explosions were heard in the capital. Pictures on social media showed a number of fires.
On Tuesday morning, the Israeli military said it had intercepted four rockets fired from Syria towards northern Israel. It said the rockets did not hit the ground.
Israel has carried out hundreds of strikes in Syria since the civil war broke out there in 2011 in an attempt to thwart what it calls Iran’s “military entrenchment” there and shipments of Iranian weapons to Lebanon’s Hezbollah movement.